|
T33076 |
Lysophosphatidic acid
|
|
|
|
Lysophosphatidic acid is a bioactive chemical. |
|
T21654 |
1-Oleoyl lysophosphatidic acid sodium
|
1-Oleoyl lysophosphatidic acid sodium salt |
LPA Receptor
|
|
1-Oleoyl lysophosphatidic acid sodium (1-Oleoyl lysophosphatidic acid sodium salt) salt is an Endogenous agonist of LPA1 and LPA2 |
|
T36768 |
1-Octadecyl Lysophosphatidic Acid
|
|
|
|
1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses... |
|
T37283 |
1-Palmitoyl Lysophosphatidic Acid (sodium salt)
|
|
|
|
1-Palmitoyl lysophosphatidic acid (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of five different G protein-coupled receptors (GPCRs) to mediate a variety of biological... |
|
T36907 |
1-Oleoyl Lysophosphatidic Acid
|
Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid |
|
|
1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through ... |
|
T36452 |
1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)
|
|
|
|
1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is... |
|
T37282 |
1-Palmitoyl Lysophosphatidic Acid
|
|
Antibacterial
|
|
1-Palmitoyl Lysophosphatidic Acid is an analog of LPA and improves the the action of ampicillin, piperacillin, and ceftazidime on various strains of P. aeruginosa via binding both Ca2+ and Mg2+. |
|
T77789 |
Oleoyl-L-alpha-lysophosphatidic acid sodium salt
|
LPA sodium salt |
|
|
Oleoyl-L-alpha-lysophosphatidic acid sodium salt is an essential cell membrane biosynthetic metabolite that mediates signal transduction by interacting with G protein-coupled receptors (GPCRs) (ie, LPA receptors). It is ... |
|
T83879 |
1-Arachidoyl Lysophosphatidic Acid sodium
|
1-Arachidoyl LPA,LPA(20:0),1-Eicosanoyl-Lysophosphatidic Acid |
|
|
1-Arachidoyl lysophosphatidic acid (1-arachidoyl LPA), a glycerophospholipid with arachidic acid at the sn-1 position, functions as an agonist for lysophosphatidic acid receptor 1 (LPA1). It effectively induces calcium m... |
|
T22834 |
H2L 5765834
|
|
LPA Receptor
,
LPL Receptor
|
|
H2L 5765834 is a lysophosphatidic acid receptors antagonist |
|
T21694 |
(R)-Lisofylline
|
(R)-Lisophylline |
STAT
|
|
(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM). (R)-Lisofylline interrupts IL-12 signaling-mediated STAT4 activation and can be used in studies about the treat... |
|
T11533 |
Z-HA155
|
CS-963 |
PDE
|
|
Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM. |
|
T83772 |
1-Linoleoyl Lysophosphatidic Acid sodium
|
1-Linoleoyl-2-hydroxy-sn-glycero-3-PA,LPA(18:2),PA(18:2(9Z,12Z)/0:0),1-Octadecadienoyl-2-hydroxy-sn-glycero-3-phosphate,18:2 Lyso PA,1-Octadecadienoyl-2-hydroxy-sn-glycero-3-PA,PA(18:2/0:0),1-Linoleoyl-2-hydroxy-sn-glycero-3-phosphate,1-Linoleoyl LPA |
|
|
1-Linoleoyl lysophosphatidic acid (1-linoleoyl LPA), a glycerophospholipid with linoleic acid at its sn-1 position, acts as an LPA2 receptor agonist and is the predominant LPA form in both mouse and human plasma. This co... |
|
T2008 |
LY294002
|
LY 294002,NSC 697286,SF 1101 |
Apoptosis
,
DNA-PK
,
Casein Kinase
,
PI3K
,
Autophagy
|
|
LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 ... |
|
T4079 |
LY-294002 hydrochloride
|
SF 1101,LY 294002,NSC 697286 |
PI3K
|
|
LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation... |
|
T7393 |
ONO-7300243
|
|
LPA Receptor
,
LPL Receptor
|
|
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM). |
|
T10415 |
Autotaxin-IN-3
|
|
PDE
|
|
Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma. |
|
T7689 |
Tetradecyl Phosphonate
|
|
LPA Receptor
|
|
Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors. |
|
T15785 |
LPA1 receptor antagonist 1
|
LPA1 R antagonist 1 |
LPA Receptor
|
|
LPA1 receptor antagonist 1(LPA1 R antagonist 1) is a selective and potent lysophosphatidic acid (LPA1) receptor antagonist (IC50 : 25 nM) for the study of idiopathic pulmonary fibrosis. |
|
T27094 |
CT-2584
|
CT2584 |
|
|
CT-2584 is an angiogenesis inhibitor and lysophosphatidic acid acyltransferase inhibitor. CT-2584 inhibits phospholipid signaling. By inhibiting CTP:choline-phosphate cytidylyltransferase (CT), CT-2584 caused de novo pho... |
|
T10381 |
AS2717638
|
|
Others
|
|
AS2717638 is an orally active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist (IC50: 38 nM for hLPA5). It also significantly improves PGF2α-, PGE2-, and AMPA-induced allodynia. |
|
T3631 |
PF-8380
|
|
PDE
|
|
PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhib... |
|
T22070 |
DBIBB
|
|
LPA Receptor
|
|
DBIBB is a non-lipid agonist of specific lysophosphatidic acid (LPA2) type 2 G-protein-coupled receptor. It is a potentially active molecule for the treatment of acute radiation syndrome caused by high intensity gamma ra... |
|
T25847 |
NAEPA
|
|
|
|
NAEPA, an LPA mimetic, is a selective agonist of the lysophosphatidic acid-1 (LPA1) receptor. |
|
T29109 |
VPC12249
|
VPC-12249,VPC 12249 |
|
|
VPC12249, a lysophosphatidic acid receptor type 1 (LPA1) antagonist, plays a functional role in osteoclast differentiation and bone resorption activity. |
|
T63645 |
ONO-9780307
|
|
|
|
ONO-9780307 is a specific antagonist of LPA1 (lysophosphatidic acid receptor 1) (IC50: 2.7 nM). |
|
T14335 |
ASP6432
|
|
LPA Receptor
|
|
ASP6432 is an antagonist of type 1 lysophosphatidic acid receptor (LPA1). For human LPA1 and rat LPA1, the IC50s are 11 nM and 30 nM , respectively. |
|
T28300 |
PAT-347 sodium
|
PAT-347,PAT347,PAT 347 |
|
|
PAT-347 is a potent inhibitor of Autotaxin (ATX), a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline. |
|
T73017 |
ONO-0740556
|
|
|
|
ONO-0740556 is a potent agonist of the Gi-coupled human lysophosphatidic acid receptor 1 (LPA1), exhibiting an EC50 value of 0.26 nM. |
|
T69647 |
UCM-05194
|
|
|
|
UCM-05194 is a potent Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1). UCM-05194 Shows Efficacy in Neuropathic Pain Amelioration. UCM-05194 stands out as the most potent and selective LPA1 receptor agonist de... |
|
T63231 |
LPA5 antagonist 1
|
|
|
|
LPA5 antagonist 1 is a selective and potent lysophosphatidic acid receptor 5 (LPA5) antagonist with an IC50 value of 32 nM. LPA5 antagonist 1 has high brain permeability and antinociceptive activity and can be used to st... |
|
T83882 |
XY-4
|
|
|
|
XY-4, a derivative of 1-palmitoyl lysophosphatidic acid (1-palmitoyl LPA094) and an agonist of peroxisome proliferator-activated receptor γ (PPARγ), effectively induces reporter gene expression in RAW 264.7 macrophages h... |
|
T16434 |
PAT-048
|
|
PDE
|
|
PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no effect on autotaxin protein and pulmonary lysophosphatidic ac... |
|
T63439 |
BMS-986020 sodium
|
|
|
|
BMS-986020 sodium is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist that inhibits bile acids and phospholipid transport proteins, and inhibits BSEP (IC50: 4.8 μM), MRP4 (IC50: 6.2 μM) and MDR3 (IC50: ... |
|
T36138 |
BMP-22
|
|
|
|
BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM). It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid... |
|
T70275 |
PAT-347
|
|
|
|
PAT-347 is a potent Autotaxin Inhibitor. Autotaxin (ATX) is a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the
bioactive lysophosphatidic acid (LPA) and choline. The ATX-LPA signali... |
|
T37691 |
Phosphatidic Acids (egg) (ammonium salt)
|
|
|
|
Phosphatidic acid is a phospholipid and an intermediate in glycerolipid biosynthesis. It is a transient intermediate in the synthesis of various phospholipid species that is synthesized de novo in cells via multiple rout... |
|
T36502 |
DCP-Rho1
|
DCP-Rho1 |
|
|
DCP-Rho1 is a fluorescent probe for the detection of sulfenic acid-containing proteins.1,2 It displays excitation/emission maxima of 560/581 nm, respectively, and has been used to visualize protein oxidation sites in sit... |
